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Science. 2002 Apr 12;296(5566):301-5.

The danger model: a renewed sense of self.

Author information

  • Ghost Lab, Laboratory for Cellular and Molecular Immunology, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Bethesda, MD 20892, USA. pcm@helix.nih.gov

Abstract

For over 50 years immunologists have based their thoughts, experiments, and clinical treatments on the idea that the immune system functions by making a distinction between self and nonself. Although this paradigm has often served us well, years of detailed examination have revealed a number of inherent problems. This Viewpoint outlines a model of immunity based on the idea that the immune system is more concerned with entities that do damage than with those that are foreign.

PMID:
11951032
[PubMed - indexed for MEDLINE]
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