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Trends Plant Sci. 2002 Apr;7(4):153-6.

Cystathionine gamma-synthase and threonine synthase operate in concert to regulate carbon flow towards methionine in plants.

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  • 1Plant Science Laboratory, Migal Galilee Technological Center, PO Box 90000, Rosh Pina 12100, Israel.


The sulfur-containing amino acid methionine is a nutritionally important essential amino acid and is the precursor of several metabolites that regulate plant growth and responses to the environment. Methionine production is largely regulated by cystathionine gamma-synthase, the first specific enzyme for its synthesis. This enzyme competes in a complex manner with threonine synthase, the last enzyme in threonine biosynthesis, for their common substrate O-phosphohomoserine. New genetic and molecular data suggest that methionine synthesis and catabolism are coordinately regulated by novel post-transcriptional and post-translational mechanisms that are associated with a regulatory part within the N-terminal part of cystathionine gamma-synthase.

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