Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Proteins. 2002 May 15;47(3):334-43.

Dissecting protein-protein recognition sites.

Author information

  • 1Department of Biochemistry, Bose Institute, P-1/12 CIT Scheme VIIM, Calcutta, India. pinak@bic.boseinst.ernet.in

Abstract

The recognition sites in 70 pairwise protein-protein complexes of known three-dimensional structure are dissected in a set of surface patches by clustering atoms at the interface. When the interface buries <2000 A2 of protein surface, the recognition sites usually form a single patch on the surface of each component protein. In contrast, larger interfaces are generally multipatch, with at least one pair of patches that are equivalent in size to a single-patch interface. Each recognition site, or patch within a site, contains a core made of buried interface atoms, surrounded by a rim of atoms that remain accessible to solvent in the complex. A simple geometric model reproduces the number and distribution of atoms within a patch. The rim is similar in composition to the rest of the protein surface, but the core has a distinctive amino acid composition, which may help in identifying potential protein recognition sites on single proteins of known structures.

Copyright 2002 Wiley-Liss, Inc.

PMID:
11948787
[PubMed - indexed for MEDLINE]
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Icon for John Wiley & Sons, Inc.
    Loading ...
    Write to the Help Desk