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Acta Psychiatr Scand. 2002 Mar;105(3):164-72.

Treatment non-adherence in affective disorders.

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  • 1Department of Psychiatry and Psychotherapy, Claremont House, Royal Victoria Infirmary, Newcastle upon Tyne, UK.

Abstract

OBJECTIVE:

The aim of this paper is to review the prevalence, predictors and methods for improving medication adherence in unipolar and bipolar affective disorders.

METHOD:

Studies were identified through Medline and PsycLit searches of English language publications between 1976 and 2001. This was supplemented by a hand search and the inclusion of selected descriptive articles on good clinical practice.

RESULTS:

Estimates of medication non-adherence for unipolar and bipolar disorders range from 10 to 60% (median 40%). This prevalence has not changed significantly with the introduction of new medications. There is evidence that attitudes and beliefs are at least as important as side-effects in predicting adherence. The limited number of empirical studies of how to reduce non-adherence offer encouraging evidence that, if recognized, the problem can be overcome.

CONCLUSION:

Only 1-2% of all publications on the treatment of affective disorders explore factors associated with medication non-adherence. This is disappointing as research and clinical data highlight the importance of extended courses of medication in improving the long-term prognosis of affective disorders.

Comment in

PMID:
11939969
[PubMed - indexed for MEDLINE]
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