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Fertil Steril. 2002 Apr;77(4):697-9.

Factors relating to a successful cryopreserved blastocyst transfer program.

Author information

  • 1Department of Gynecology and Obstetrics, Stanford University Medical Center, Stanford, California 94305, USA. behr@stanford.edu

Abstract

OBJECTIVE:

To review the authors' experience in a successful frozen blastocyst program.

DESIGN:

Retrospective study.

SETTING:

University IVF program.

PATIENTS:

Women of all ages undergoing 64 frozen blastocyst nondonor thaw cycles.

INTERVENTION(S):

Thaw cycles with day 5 or day 6 frozen blastocysts replaced into luteal day 5 endometrium in natural or programmed cycles; cryopreservation of blastocysts by Menezo two-step protocol and Testart slow cool program; thawing by two step thaw protocol.

MAIN OUTCOME MEASURE(S):

Implantation, clinical pregnancy, and delivery rates.

RESULT(S):

The implantation rate was 16% and was similar with day 5 frozen blastocysts and day 6 frozen blastocysts cycles. The clinical pregnancy rate was 36% and the delivery rate was 27%, with no significant difference between day 5 and 6 blastocysts.

CONCLUSION(S):

Blastocyst cryopreservation is a viable option for patients of all ages and complements fresh blastocyst culture and transfer. The presence of good quality blastocysts for freezing on day 5 and day 6 yields comparable results and is critical for the success of thaw cycles.

PMID:
11937118
[PubMed - indexed for MEDLINE]
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