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    Pigment Cell Res. 2002 Apr;15(2):82-6.

    The pallidin (Pldn) gene and the role of SNARE proteins in melanosome biogenesis.

    Falcón-Pérez JM, Dell'Angelica EC.

    Source

    Department of Human Genetics, University of California at Los Angeles (UCLA) School of Medicine, 90095, USA.

    Abstract

    This review focuses on the product of the pallidin (Pldn) gene, one of a number of genes that in mice are associated with pigmentation defects and platelet dense granule deficiency. A similar combination of defects is also observed in patients suffering from Hermansky-Pudlak (HPS) and Chediak-Higashi (CHS) syndromes. Pldn encodes a novel, approximately 20-kDa protein that is expressed ubiquitously in mammalian tissues. The pallidin protein was found to bind to syntaxin 13, a member of the syntaxin family of soluble N-ethylmaleimide-sensitive factor attachment protein receptors (SNAREs). As SNARE proteins mediate fusion of intracellular membranes, pallidin may play a role in membrane fusion events required for melanosome biogenesis.

    PMID:
    11936273
    [PubMed - indexed for MEDLINE]

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