Display Settings:

Format

Send to:

Choose Destination
    Trends Genet. 2002 Apr;18(4):193-201.

    The sterol-sensing domain: multiple families, a unique role?

    Source

    The Wellcome Trust Sanger Institute, Hinxton, Cambridge CB10 1SA, UK. pek@sanger.ac.uk

    Abstract

    The "sterol-sensing domain" (SSD) is conserved across phyla and is present in several membrane proteins, such as Patched (a Hedgehog receptor) and NPC-1 (the protein defective in Niemann-Pick type C1 disease). The role of the SSD is perhaps best understood from the standpoint of its involvement in cholesterol homeostasis. This article discusses how the SSD appears to function as a regulatory domain involved in linking vesicle trafficking and protein localization with such varied processes as cholesterol homeostasis, cell signalling and cytokinesis.

    PMID:
    11932020
    [PubMed - indexed for MEDLINE]

      Supplemental Content

      Click here to read

      Recent activity

      Your browsing activity is empty.

      Activity recording is turned off.

      Turn recording back on

      See more...
      Write to the Help Desk