Adv Genet. 2002;46:339-60.

RNAi (Nematodes: Caenorhabditis elegans).

Source

Program in Molecular Medicine, University of Massachusetts Medical School, Worcester 01605, USA.

Abstract

RNA interference in Caenorhabditis elegans is a type of homology dependent posttranscriptional gene silencing induced by dsRNA. In this chapter we describe the history of the discovery of RNAi, its systemic nature, inheritance, and connection to other homology-dependent silencing phenomena like co-suppression and transcriptional gene silencing. We discuss RNAi-deficient mutants in C. elegans as well as characterized components of the RNAi, pathway, the molecular mechanism of RNAi, and its possible role in development and immunity.

PMID:: 11931230; [PubMed - indexed for MEDLINE]

Supplemental Content

Save items

Related citations in PubMed

The rde-1 gene, RNA interference, and transposon silencing in C. elegans. [Cell. 1999]
The rde-1 gene, RNA interference, and transposon silencing in C. elegans.
Tabara H, Sarkissian M, Kelly WG, Fleenor J, Grishok A, Timmons L, Fire A, Mello CC. Cell. 1999 Oct 15; 99(2):123-32.
Genetic requirements for inheritance of RNAi in C. elegans. [Science. 2000]
Genetic requirements for inheritance of RNAi in C. elegans.
Grishok A, Tabara H, Mello CC. Science. 2000 Mar 31; 287(5462):2494-7.
A genetic link between co-suppression and RNA interference in C. elegans. [Nature. 2000]
A genetic link between co-suppression and RNA interference in C. elegans.
Ketting RF, Plasterk RH. Nature. 2000 Mar 16; 404(6775):296-8.
Review RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences. [Cold Spring Harb Symp Quant Bi...]
Review RNA interference, transposon silencing, and cosuppression in the Caenorhabditis elegans germ line: similarities and differences.
Robert VJ, Vastenhouw NL, Plasterk RH. Cold Spring Harb Symp Quant Biol. 2004; 69:397-402.
Review RNAi mechanisms in Caenorhabditis elegans. [FEBS Lett. 2005]
Review RNAi mechanisms in Caenorhabditis elegans.
Grishok A. FEBS Lett. 2005 Oct 31; 579(26):5932-9. Epub 2005 Aug 9.

See reviews... See all...

Cited by 13 PubMed Central articles

Protocols for gene silencing in schistosomes. [Exp Parasitol. 2007]
Protocols for gene silencing in schistosomes.
Ndegwa D, Krautz-Peterson G, Skelly PJ. Exp Parasitol. 2007 Nov; 117(3):284-91. Epub 2007 Aug 15.
Schistosoma mansoni: the dicer gene and its expression. [Exp Parasitol. 2008]
Schistosoma mansoni: the dicer gene and its expression.
Krautz-Peterson G, Skelly PJ. Exp Parasitol. 2008 Jan; 118(1):122-8. Epub 2007 Jul 19.
The establishment of neuronal properties is controlled by Sox4 and Sox11. [Genes Dev. 2006]
The establishment of neuronal properties is controlled by Sox4 and Sox11.
Bergsland M, Werme M, Malewicz M, Perlmann T, Muhr J. Genes Dev. 2006 Dec 15; 20(24):3475-86.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

RNAi (Nematodes: Caenorhabditis elegans).
RNAi (Nematodes: Caenorhabditis elegans).
Adv Genet. 2002 ;46:339-60.

PubMed
Assault victimization and suicidal ideation or behavior within a national sample...
Assault victimization and suicidal ideation or behavior within a national sample of U.S. adults.
Suicide Life Threat Behav. 2002 Spring ;32(1):42-50.

PubMed
Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease.
Open clinical trial of rifabutin and clarithromycin therapy in Crohn's disease.
Dig Liver Dis. 2002 Jan ;34(1):22-8.

PubMed
Use of complementary and alternative treatments by individuals with fibromyalgia...
Use of complementary and alternative treatments by individuals with fibromyalgia syndrome.
J Am Acad Nurse Pract. 2000 Aug ;12(8):311-6.

PubMed
D-glyceric aciduria in a six-month-old boy presenting with West syndrome and aut...
D-glyceric aciduria in a six-month-old boy presenting with West syndrome and autistic behaviour.
Neuropediatrics. 2002 Feb ;33(1):47-50.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

RNAi (Nematodes: Caenorhabditis elegans).

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

Supplemental Content

Save items

Related citations in PubMed

Cited by 13 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information