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1: Hum Cell. 2001 Dec;14(4):257-60.Links

[Mechanisms of drug resistance and reversal of the resistance]

[Article in Japanese]

Akiyama S.

Department of Cancer Chemotherapy, Institute for Cancer Research, Faculty of Medicine, Kagoshima University, 8-35-1 Sakuragaoka, Kagoshima 890-8520, Japan. akiyamas@m3.kufm.kagoshima-u.ac.jp

The mechanisms for the resistance to anticancer agents have been vigorously studied and many factors that are involved in the resistance were found. Among the members of ABC transporter superfamily, P-glycoprotein, MRP1-5 and BCRP are involved in the drug resistance. LRP, identified as the major vault protein, is also related to drug resistance.

PMID: 11925925 [PubMed - indexed for MEDLINE]