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Pharmacol Ther. 2001 Nov-Dec;92(2-3):179-212.

Multiplicity of mechanisms of serotonin receptor signal transduction.

Author information

  • 1The Research Service of the Ralph H. Johnson Veterans Affairs Medical Center, Charleston, SC 29401, USA. raymondj@musc.edu

Abstract

The serotonin (5-hydroxytryptamine, 5-HT) receptors have been divided into 7 subfamilies by convention, 6 of which include 13 different genes for G-protein-coupled receptors. Those subfamilies have been characterized by overlapping pharmacological properties, amino acid sequences, gene organization, and second messenger coupling pathways. Post-genomic modifications, such as alternative mRNA splicing or mRNA editing, creates at least 20 more G-protein-coupled 5-HT receptors, such that there are at least 30 distinct 5-HT receptors that signal through G-proteins. This review will focus on what is known about the signaling linkages of the G-protein-linked 5-HT receptors, and will highlight some fascinating new insights into 5-HT receptor signaling.

PMID:
11916537
[PubMed - indexed for MEDLINE]
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