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1: FEBS Lett. 2002 Feb 20;513(1):129-34.Click here to read Links

Protein domain analysis in the era of complete genomes.

Copley RR, Doerks T, Letunic I, Bork P.

EMBL, Meyerhofstrasse 1, Heidelberg, Germany.

Domains present one of the most useful levels at which to understand protein function, and domain family-based analysis has had a profound impact on the study of individual proteins. Protein domain discovery has been progressing steadily over the past 30 years. What are the realistically achievable goals of sequence-based domain analysis, and how far off are they for the sequences encoded in eukaryotic genomes? Here we address some of the issues involved in better coverage of sequence-based domain annotation, and the integration of these results within the wider context of genomes, structures and function.

PMID: 11911892 [PubMed - indexed for MEDLINE]