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FEBS Lett. 2002 Feb 20;513(1):77-84.

The phosphatidylinositol 3-phosphate-binding FYVE finger.

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  • 1Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway. h.a.stenmark@farmasi.uio.no


The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.

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