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FEBS Lett. 2002 Feb 20;513(1):77-84.

The phosphatidylinositol 3-phosphate-binding FYVE finger.

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  • 1Department of Biochemistry, The Norwegian Radium Hospital, Oslo, Norway.


The FYVE zinc finger domain is conserved from yeast (five proteins) to man (27 proteins). It functions in the membrane recruitment of cytosolic proteins by binding to phosphatidylinositol 3-phosphate (PI3P), which is found mainly on endosomes. Here we review recent work that sheds light on the targeting of FYVE finger proteins to PI3P-containing membranes, and how these proteins serve to regulate multiple cellular functions.

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