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FEBS Lett. 2002 Feb 20;513(1):19-23.

VHS domain -- a longshoreman of vesicle lines.

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  • 1Department of Pediatrics, University of Tampere, Tampere, Finland.


The VHS (Vps-27, Hrs and STAM) domain is a 140 residue long domain present in the very NH2-terminus of at least 60 proteins. Based on their functional characteristics and on recent data on the involvement of VHS in cargo recognition in trans-Golgi, VHS domains are considered to have a general membrane targeting/cargo recognition role in vesicular trafficking. Structurally, VHS is a right-handed superhelix of eight helices with charged surface patches probably serving as sites of protein-protein recognition and docking.

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