Insulin-like growth factor-I: compartmentalization...[News Physiol Sci. 2002]

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1: News Physiol Sci. 2002 Apr;17:82-5. Links

Insulin-like growth factor-I: compartmentalization within the somatotropic axis?

Butler AA, Yakar S, LeRoith D.

The Vollum Institute, Oregon Health Sciences University, Portland, Oregon 97201, USA.

Insulin-like growth factor-I (IGF-I) is essential for normal growth; igf-1 gene mutations are associated with extreme growth retardation in mice and, very rarely, in humans. The relative contributions of tissue vs. endocrine (hepatic) IGF-I to the regulation of growth has been a fundamental question. New gene targeting technologies are providing answers for these questions.

PMID: 11909998 [PubMed - indexed for MEDLINE]

GH, IGF-I, and growth. [J Pediatr Endocrinol Metab. 2004]
A transgenic model to determine the physiological role of liver-derived insulin-like growth factor I. [Minerva Endocrinol. 2002]
The response of the hepatic insulin-like growth factor system to growth hormone and dexamethasone in calves. [J Endocrinol. 2003]
[Physiology of somatotropic axis: interest of gene inactivation experiments] [Bull Acad Natl Med. 2003]
PERK eIF2alpha kinase regulates neonatal growth by controlling the expression of circulating insulin-like growth factor-I derived from the liver. [Endocrinology. 2003]
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Insulin-like growth factor-I: compartmentalization within the somatotropic axis?

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