Plasminogen activator inhibitor 1: physiological a...[News Physiol Sci. 2002]

SearchDatabase nameforSearch term

Advanced Search (beta)

Your browser version may not work well with NCBI's Web applications. More information here...

Display Show

All: 1

Review: 1

Click to change filter selection through MyNCBI.

1: News Physiol Sci. 2002 Apr;17:56-61. Links

Plasminogen activator inhibitor 1: physiological and pathophysiological roles.

Binder BR, Christ G, Gruber F, Grubic N, Hufnagl P, Krebs M, Mihaly J, Prager GW.

Department of Vascular Biology and Thrombosis Research, University of Vienna, A-1090 Vienna, Austria. bernd.blinder@univie.ac.at

Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.

PMID: 11909993 [PubMed - indexed for MEDLINE]

Modulation of tissue plasminogen activator and plasminogen activator inhibitor-1 by transforming growth factor-beta in human retinal glial cells. [Invest Ophthalmol Vis Sci. 2002]
The pathophysiological relevance of PAI-1 in cardiovascular diseases and the development of monoclonal antibodies as PAI-1 inhibitors. [Verh K Acad Geneeskd Belg. 2006]
[Specific inhibitors of plasminogen activators] [Postepy Hig Med Dosw. 1993]
The plasminogen activation system in skeletal muscle regeneration: antagonistic roles of urokinase-type plasminogen activator (uPA) and its inhibitor (PAI-1). [Front Biosci. 2005]
Plasminogen activator system and vascular disease. [Curr Vasc Pharmacol. 2006]
» See all Related Articles...

Display Show

Plasminogen activator inhibitor 1: physiological and pathophysiological roles.

Related Articles