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    News Physiol Sci. 2002 Apr;17:56-61.

    Plasminogen activator inhibitor 1: physiological and pathophysiological roles.

    Binder BR, Christ G, Gruber F, Grubic N, Hufnagl P, Krebs M, Mihaly J, Prager GW.

    Department of Vascular Biology and Thrombosis Research, University of Vienna, A-1090 Vienna, Austria. bernd.blinder@univie.ac.at

    Plasminogen activator inhibitor 1 (PAI-1) inhibits plasminogen activators (u-PA and t-PA) by forming stable complexes endocytosed via a low-density lipoprotein receptor superfamily member-dependent mechanism. PAI-1 circulates actively in plasma and latently in platelets but is also secreted and deposited into the matrix by several cells, where it participates in tissue repair processes.

    PMID: 11909993 [PubMed - indexed for MEDLINE]

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