Gene-specific regulation by general translation fa...[Cell. 2002]

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1: Cell. 2002 Feb 22;108(4):545-56. Links

Gene-specific regulation by general translation factors.

Dever TE.

Laboratory of Gene Regulation and Development, National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD 20892, USA. t.dever@box-t.nih.gov

Protein synthesis is the ultimate step of gene expression and a key control point for regulation. In particular, it enables cells to rapidly manipulate protein production without new mRNA synthesis, processing, or export. Recent studies have enhanced our understanding of the translation initiation process and helped elucidate how modifications of the general translational machinery regulate gene-specific protein production.

PMID: 11909525 [PubMed - indexed for MEDLINE]

Involvement of an initiation factor and protein phosphorylation in translational control of GCN4 mRNA. [Trends Biochem Sci. 1990]
Regulation of translation initiation and modulation of cellular physiology. [Trends Biochem Sci. 1993]
Diversity of mechanisms in the regulation of translation in prokaryotes and lower eukaryotes. [Curr Opin Genet Dev. 1992]
Regulation of translation in eukaryotic systems. [Annu Rev Cell Biol. 1992]
Gene-specific translational control of the yeast GCN4 gene by phosphorylation of eukaryotic initiation factor 2. [Mol Microbiol. 1993]
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Gene-specific regulation by general translation factors.

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