Cell. 2002 Feb 22;108(4):501-12.

Integrating mRNA processing with transcription.

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Sir William Dunn School of Pathology, University of Oxford, South Parks Road, Oxford OX1 3RE, United Kingdom. nicholas.proudfoot@path.ox.ac.uk

Abstract

The messenger RNA processing reactions of capping, splicing, and polyadenylation occur cotranscriptionally. They not only influence one another's efficiency and specificity, but are also coordinated by transcription. The phosphorylated CTD of RNA polymerase II provides key molecular contacts with these mRNA processing reactions throughout transcriptional elongation and termination.

PMID:: 11909521; [PubMed - indexed for MEDLINE]

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