Display Settings:


Send to:

Choose Destination
See comment in PubMed Commons below
Cell. 2002 Feb 22;108(4):489-500.

Epigenetic codes for heterochromatin formation and silencing: rounding up the usual suspects.

Author information

  • 1Department of Biology, Washington University, One Brookings Drive, St. Louis, MO 63130, USA.


Recent results from diverse organisms point to a self-reinforcing network of interactions among the three best-characterized covalent modifications that mark heterochromatin: histone hypoacetylation, histone H3-Lys9 methylation, and cytosine methylation. These modification systems suggest a mechanistic basis for spreading of heterochromatin over large domains and for stable epigenetic inheritance of the silent state. All three modifications used in packaging heterochromatin are also used in stable silencing of euchromatic genes.

Comment in

[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

How to join PubMed Commons

    Supplemental Content

    Icon for Elsevier Science
    Loading ...
    Write to the Help Desk