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Cell. 2002 Feb 22;108(4):475-87.

Cooperation between complexes that regulate chromatin structure and transcription.

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  • 1Department of Molecular Biology, Massachusetts General Hospital, Boston, MA 02114, USA.


Chromatin structure creates barriers for each step in eukaryotic transcription. Here we discuss how the activities of two major classes of chromatin-modifying complexes, ATP-dependent remodeling complexes and HAT or HDAC complexes, might be coordinated to create a DNA template that is accessible to the general transcription apparatus.

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