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Cell. 2002 Feb 22;108(4):453-63.

The RNA polymerase II machinery: structure illuminates function.

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  • 1Department of Molecular Genetics and Microbiology, Robert Wood Johnson Medical School, Piscataway, NJ 08854, USA.


Essential components of the eukaryotic transcription apparatus include RNA polymerase II, a common set of initiation factors, and a Mediator complex that transmits regulatory information to the enzyme. Insights into mechanisms of transcription have been gained by three-dimensional structures for many of these factors and their complexes, especially for yeast RNA polymerase II at atomic resolution.

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