[30 years: Happy birthday, GPCR. The bradykinin B2...[Nephrologie. 2002]

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1: Nephrologie. 2002;23(1):39-41.Links

[30 years: Happy birthday, GPCR. The bradykinin B2 receptor: an alternative and antiproliferative pathway]

[Article in French]

Duchêne J, Schanstra J, Cellier E, Bascands JL, Girolami JP.

INSERM U 388 Pharmacologie moléculaire et phsiopathologie rénale, CHU Rangueil, Toulouse. jean-pierre.girolami@toulouse.inserm.fr.

The bradykinin B2 receptor which belongs to the G-protein-coupled receptor (GPCR) family is known for its proliferative effects. The mitogenic signalling pathways used are "classical" pathways for GPCRs. Recent data from our laboratory show that bradykinin can also induce anti-mitogenic effects in proliferating cells using an "alternative" signal transduction pathway involving a protein tyrosine phosphatase. Besides this alternative signalling pathway for the B2 receptor, a novel concept of GPCR signalling is described.

PMID: 11908480 [PubMed - indexed for MEDLINE]

A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation.
J Biol Chem. 2002 Oct 25; 277(43):40375-83. Epub 2002 Aug 12.

[J Biol Chem. 2002]
Platelet factor 4 inhibits FGF2-induced endothelial cell proliferation via the extracellular signal-regulated kinase pathway but not by the phosphatidylinositol 3-kinase pathway.
Blood. 2002 Nov 1; 100(9):3087-94.

[Blood. 2002]
Mitogenic signalling by B2 bradykinin receptor in epithelial breast cells.
J Cell Physiol. 2004 Oct; 201(1):84-96.

[J Cell Physiol. 2004]
ReviewSignal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: lessons from bradykinin signaling.
Curr Med Chem. 2000 Sep; 7(9):911-43.

[Curr Med Chem. 2000]
ReviewBradykinin signalling to MAP kinase: cell-specific connections versus principle mitogenic pathways.
Biol Chem. 2001 Jan; 382(1):49-55.

[Biol Chem. 2001]
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