J Virol. 2002 Apr;76(8):4108-12.

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication.

Allen TM, Mortara L, Mothé BR, Liebl M, Jing P, Calore B, Piekarczyk M, Ruddersdorf R, O'Connor DH, Wang X, Wang C, Allison DB, Altman JD, Sette A, Desrosiers RC, Sutter G, Watkins DI.

Source

Wisconsin Regional Primate Research Center, University of Wisconsin, Madison, Wisconsin 53715, USA.

Abstract

The regulatory proteins of human immunodeficiency virus may represent important vaccine targets. Here we assessed the role of Tat-specific cytotoxic T lymphocytes (CTL) in controlling pathogenic simian immunodeficiency virus SIVmac239 replication after using a DNA-prime, vaccinia virus Ankara-boost vaccine regimen. Despite the induction of Tat-specific CTL, there was no significant reduction in either peak or viral set point compared to that of controls.

PMID:: 11907251; [PubMed - indexed for MEDLINE]
PMCID:: PMC136098

Free PMC Article

Images from this publication.See all images (3) Free text

Publication Types, MeSH Terms, Substances, Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

COS Scholar Universe

Medical

HIV InSite

Supplemental Content

Save items

Related citations in PubMed

Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239. [J Virol. 2003]
Multispecific vaccine-induced mucosal cytotoxic T lymphocytes reduce acute-phase viral replication but fail in long-term control of simian immunodeficiency virus SIVmac239.
Vogel TU, Reynolds MR, Fuller DH, Vielhuber K, Shipley T, Fuller JT, Kunstman KJ, Sutter G, Marthas ML, Erfle V, et al. J Virol. 2003 Dec; 77(24):13348-60.
Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239. [J Virol. 2002]
Immunization of rhesus macaques with a DNA prime/modified vaccinia virus Ankara boost regimen induces broad simian immunodeficiency virus (SIV)-specific T-cell responses and reduces initial viral replication but does not prevent disease progression following challenge with pathogenic SIVmac239.
Horton H, Vogel TU, Carter DK, Vielhuber K, Fuller DH, Shipley T, Fuller JT, Kunstman KJ, Sutter G, Montefiori DC, et al. J Virol. 2002 Jul; 76(14):7187-202.
Multigene DNA priming-boosting vaccines protect macaques from acute CD4+-T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge. [J Virol. 2003]
Multigene DNA priming-boosting vaccines protect macaques from acute CD4+-T-cell depletion after simian-human immunodeficiency virus SHIV89.6P mucosal challenge.
Doria-Rose NA, Ohlen C, Polacino P, Pierce CC, Hensel MT, Kuller L, Mulvania T, Anderson D, Greenberg PD, Hu SL, et al. J Virol. 2003 Nov; 77(21):11563-77.
Review Protection against human immunodeficiency virus type 2 and simian immunodeficiency virus in macaques vaccinated against human immunodeficiency virus type 2. [AIDS Res Hum Retroviruses. 1996]
Review Protection against human immunodeficiency virus type 2 and simian immunodeficiency virus in macaques vaccinated against human immunodeficiency virus type 2.
Biberfeld G, Thorstensson R, Putkonen P. AIDS Res Hum Retroviruses. 1996 Mar 20; 12(5):443-6.
Review HIV vaccine development. [Top HIV Med. 2010]
Review HIV vaccine development.
Watkins DI. Top HIV Med. 2010 Apr-May; 18(2):35-6.

See reviews... See all...

Cited by 31 PubMed Central articles

Timing of immune escape linked to success or failure of vaccination. [PLoS One. 2010]
Timing of immune escape linked to success or failure of vaccination.
Reece JC, Loh L, Alcantara S, Fernandez CS, Stambas J, Sexton A, De Rose R, Petravic J, Davenport MP, Kent SJ. PLoS One. 2010 Sep 16; 5(9). Epub 2010 Sep 16.
SIVsm Tat, Rev, and Nef1: functional characteristics of r-GV internalization on isotypes, cytokines, and intracellular degradation. [BMC Biotechnol. 2010]
SIVsm Tat, Rev, and Nef1: functional characteristics of r-GV internalization on isotypes, cytokines, and intracellular degradation.
Sremac M, Stuart ES. BMC Biotechnol. 2010 Jul 19; 10:54. Epub 2010 Jul 19.
Review Is an HIV vaccine possible? [Braz J Infect Dis. 2009]
Review Is an HIV vaccine possible?
Wilson NA, Watkins DI. Braz J Infect Dis. 2009 Aug; 13(4):304-10.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
References for this PMC Article
Citation referenced in PubMed article. Only valid for PubMed citations that are also in PMC.
Free in PMC
Free full text articles in PMC
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 r...
Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication.
J Virol. 2002 Apr ;76(8):4108-12.

PubMed
Long-distance base pairing in flock house virus RNA1 regulates subgenomic RNA3 s...
Long-distance base pairing in flock house virus RNA1 regulates subgenomic RNA3 synthesis and RNA2 replication.
J Virol. 2002 Apr ;76(8):3905-19.

PubMed
Antiviral effects of an iminosugar derivative on flavivirus infections.
Antiviral effects of an iminosugar derivative on flavivirus infections.
J Virol. 2002 Apr ;76(8):3596-604.

PubMed
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for ...
IFN-gamma-inducible protein 10 (IP-10; CXCL10)-deficient mice reveal a role for IP-10 in effector T cell generation and trafficking.
J Immunol. 2002 Apr 1 ;168(7):3195-204.

PubMed
Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epiderm...
Src-mediated inter-receptor cross-talk between the Na+/K+-ATPase and the epidermal growth factor receptor relays the signal from ouabain to mitogen-activated protein kinases.
J Biol Chem. 2002 May 24 ;277(21):18694-702. Epub 2002 Mar 20 .

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Tat-vaccinated macaques do not control simian immunodeficiency virus SIVmac239 replication.

Source

Abstract

Publication Types, MeSH Terms, Substances, Grant Support

Publication Types

MeSH Terms

Substances

Grant Support

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 31 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information