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Nat Rev Immunol. 2001 Dec;1(3):233-9.

Transplantation tolerance from a historical perspective.

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  • 1Transplantation Institute, University of Pittsburgh Medical Center, Pennsylvania 15213, USA. starzlte@msx.upmc.edu


Although transplantation immunology as a distinctive field began with the development of experimental models that showed the feasibility of bone marrow transplantation, organ engraftment was accomplished first in humans, and was thought for many years to occur by drastically different mechanisms. Here, we present our view of the concepts of allograft acceptance and acquired tolerance from a historical perspective, and attempt to amalgamate them into simple and unifying rules that might guide improvements in clinical therapy.

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