FEBS Lett. 2002 Mar 6;514(1):26-9.

Elongation factor-2 kinase and its newly discovered relatives.

Source

Department of Pharmacology, University of Medicine and Dentistry of New Jersey-Robert Wood Johnson Medical School, Piscataway NJ 08854, USA. ryazanag@umdnj.edu

Abstract

Phosphorylation of elongation factor-2 (eEF-2) by the highly specific eEF-2 kinase results in eEF-2 inactivation and, therefore, may regulate the global rate of protein synthesis in animal cells. Cloning and sequencing of eEF-2 kinase led to the discovery of a new family of protein kinases, named alpha-kinases, whose catalytic domains display no sequence homology to conventional eukaryotic protein kinases. Several mammalian alpha-kinases have recently been cloned. Two of these alpha-kinases, named channel-kinases 1 and 2 (ChaK1 and ChaK2) represent a new type of signaling molecules that are protein kinases fused to ion channels.

PMID:: 11904175; [PubMed - indexed for MEDLINE]

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Supplemental Content

Save items

Related citations in PubMed

Mapping the functional domains of elongation factor-2 kinase. [Biochemistry. 2000]
Mapping the functional domains of elongation factor-2 kinase.
Pavur KS, Petrov AN, Ryazanov AG. Biochemistry. 2000 Oct 10; 39(40):12216-24.
Regulation of elongation factor-2 kinase by pH. [Biochemistry. 2002]
Regulation of elongation factor-2 kinase by pH.
Dorovkov MV, Pavur KS, Petrov AN, Ryazanov AG. Biochemistry. 2002 Nov 12; 41(45):13444-50.
Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase. [Biochim Biophys Acta. 2008]
Determinants for substrate phosphorylation by Dictyostelium myosin II heavy chain kinases A and B and eukaryotic elongation factor-2 kinase.
Crawley SW, Côté GP. Biochim Biophys Acta. 2008 Jun; 1784(6):908-15. Epub 2008 Mar 12.
Review Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates. [New Biol. 1990]
Review Phosphorylation of elongation factor 2: a key mechanism regulating gene expression in vertebrates.
Ryazanov AG, Spirin AS. New Biol. 1990 Oct; 2(10):843-50.
Review Alpha-kinases: analysis of the family and comparison with conventional protein kinases. [Prog Biophys Mol Biol. 2004]
Review Alpha-kinases: analysis of the family and comparison with conventional protein kinases.
Drennan D, Ryazanov AG. Prog Biophys Mol Biol. 2004 May; 85(1):1-32.

See reviews... See all...

Cited by 16 PubMed Central articles

Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae. [Mol Cell Proteomics. 2011]
Proteomic evaluation and validation of cathepsin D regulated proteins in macrophages exposed to Streptococcus pneumoniae.
Bewley MA, Pham TK, Marriott HM, Noirel J, Chu HP, Ow SY, Ryazanov AG, Read RC, Whyte MK, Chain B, et al. Mol Cell Proteomics. 2011 Jun; 10(6):M111.008193. Epub 2011 Apr 7.
The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k. [Cell Signal. 2011]
The channel-kinase TRPM7 regulates phosphorylation of the translational factor eEF2 via eEF2-k.
Perraud AL, Zhao X, Ryazanov AG, Schmitz C. Cell Signal. 2011 Mar; 23(3):586-93. Epub 2010 Nov 25.
Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway. [Am J Pathol. 2010]
Resveratrol regulates pathologic angiogenesis by a eukaryotic elongation factor-2 kinase-regulated pathway.
Khan AA, Dace DS, Ryazanov AG, Kelly J, Apte RS. Am J Pathol. 2010 Jul; 177(1):481-92. Epub 2010 May 14.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Elongation factor-2 kinase and its newly discovered relatives.
Elongation factor-2 kinase and its newly discovered relatives.
FEBS Lett. 2002 Mar 6 ;514(1):26-9.

PubMed
Water drinking as a treatment for orthostatic syndromes.
Water drinking as a treatment for orthostatic syndromes.
Am J Med. 2002 Apr 1 ;112(5):355-60.

PubMed
Genetic variability of the human filarial parasite, Wuchereria bancrofti in Sout...
Genetic variability of the human filarial parasite, Wuchereria bancrofti in South India.
Acta Trop. 2002 Apr ;82(1):67-76.

PubMed
Community factors associated with malaria prevention by mosquito nets: an explor...
Community factors associated with malaria prevention by mosquito nets: an exploratory study in rural Burkina Faso.
Trop Med Int Health. 2002 Mar ;7(3):240-8.

PubMed
Tissue shrinkage and unbiased stereological estimation of particle number and si...
Tissue shrinkage and unbiased stereological estimation of particle number and size.
J Microsc. 2001 Dec ;204(Pt 3):232-46.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to: