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Nat Rev Cancer. 2001 Dec;1(3):181-93.

The promise of retinoids to fight against cancer.

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  • 1Dipartimento di Patologia Generale e Oncologia, Seconda Universit√† degli Studi di Napoli, Italy.


Retinoids have a reputation for being both detrimental and beneficial: they are teratogens, but they also have tumour-suppressive capacity. Cell biology and genetics have significantly improved our understanding of the mechanisms that underlie the anti-proliferative action of retinoids. Recent elucidation of the pathways that are activated by retinoids will help us to exploit the beneficial aspects of this powerful class of compounds for cancer therapy and prevention.

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