Display Settings:

Format

Send to:

Choose Destination
See comment in PubMed Commons below
Circulation. 2002 Mar 19;105(11):1304-10.

Effects of long-term biventricular stimulation for resynchronization on echocardiographic measures of remodeling.

Author information

  • 1Cardiomyopathy and Arrhythmia Research and Education Center, University of California, San Francisco, Calif, USA. saxon@medicine.ucsf.edu

Abstract

BACKGROUND:

Long-term ventricular resynchronization therapy improves symptom status. Changes in left ventricular remodeling have not been adequately evaluated.

METHODS AND RESULTS:

Fifty-three patients with systolic heart failure and bundle-branch block underwent implantation of biventricular stimulation (BVS) devices as part of a randomized trial. Echocardiograms were acquired at randomization and at 6-week intervals until completion of 12 weeks of continuous BVS. There were no changes in heart rate or QRS duration after 12 weeks of BVS. Serum norepinephrine values did not change with BVS. After 12 weeks of BVS, left atrial volume decreased. Left ventricular end-systolic and end-diastolic dimensions and left ventricular end-systolic volume also decreased after 12 weeks of BVS. Sphericity index did not change. Measures of systolic function, including left ventricular outflow tract and aortic velocity time integral and myocardial performance index, improved.

CONCLUSIONS:

Long-term resynchronization therapy results in atrial and ventricular reverse remodeling and improved hemodynamics.

PMID:
11901040
[PubMed - indexed for MEDLINE]
Free full text
PubMed Commons home

PubMed Commons

0 comments
How to join PubMed Commons

    Supplemental Content

    Full text links

    Icon for HighWire
    Loading ...
    Write to the Help Desk