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Biochimie. 2002 Jan;84(1):95-102.

BRCA1 and BRCA2 in hereditary breast cancer.

Author information

  • 1Department of Hematology/Oncology, Cancer Biology Program, Beth Israel Deaconess Medical Center and Harvard Medical School, 77 Avenue Louis Pasteur, HIM 925, Boston, MA 02215, USA. rscully@caregroup.harvard.edu


The hereditary breast and ovarian cancer susceptibility genes, BRCA1 and BRCA2, have established roles in genome integrity maintenance and in the control of homologous recombination. Recent work has produced valuable insights into the mechanisms of action of the gene products. This review summarizes some of these advances, and attempts to place them in the context of known functions of the genes.

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