Nat Rev Cancer. 2001 Oct;1(1):55-67.

APC, signal transduction and genetic instability in colorectal cancer.

Source

Department of Human and Clinical Genetics, and Center for Biomedical Genetics, Leiden University Medical Center, The Netherlands. r.fodde@lumc.nl

Abstract

Colorectal cancer arises through a gradual series of histological changes, each of which is accompanied by a specific genetic alteration. In general, an intestinal cell needs to comply with two essential requirements to develop into a cancer: it must acquire selective advantage to allow for the initial clonal expansion, and genetic instability to allow for multiple hits in other genes that are responsible for tumour progression and malignant transformation. Inactivation of APC--the gene responsible for most cases of colorectal cancer--might fulfil both requirements.

PMID:: 11900252; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Medical

Supplemental Content

Save items

Related citations in PubMed

Review The APC gene in colorectal cancer. [Eur J Cancer. 2002]
Review The APC gene in colorectal cancer.
Fodde R. Eur J Cancer. 2002 May; 38(7):867-71.
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines. [Oncogene. 2001]
Extensive characterization of genetic alterations in a series of human colorectal cancer cell lines.
Gayet J, Zhou XP, Duval A, Rolland S, Hoang JM, Cottu P, Hamelin R. Oncogene. 2001 Aug 16; 20(36):5025-32.
Review Wingless signaling pathway family relation to colon cancer. Have we come full circle? [Saudi Med J. 2005]
Review Wingless signaling pathway family relation to colon cancer. Have we come full circle?
Al-Kuraya KS, Bhatia KG. Saudi Med J. 2005 Jan; 26(1):19-23.
Review APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer. [Eur J Surg Oncol. 2003]
Review APC, beta-Catenin and hTCF-4; an unholy trinity in the genesis of colorectal cancer.
Bright-Thomas RM, Hargest R. Eur J Surg Oncol. 2003 Mar; 29(2):107-17.
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. [BMC Cancer. 2005]
Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study.
Lüchtenborg M, Weijenberg MP, Wark PA, Saritas AM, Roemen GM, van Muijen GN, de Bruïne AP, van den Brandt PA, de Goeij AF. BMC Cancer. 2005 Dec 15; 5:160. Epub 2005 Dec 15.

See reviews... See all...

Cited by 83 PubMed Central articles

Wnt signalling pathway parameters for mammalian cells. [PLoS One. 2012]
Wnt signalling pathway parameters for mammalian cells.
Tan CW, Gardiner BS, Hirokawa Y, Layton MJ, Smith DW, Burgess AW. PLoS One. 2012; 7(2):e31882. Epub 2012 Feb 21.
N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis. [EMBO Mol Med. 2012]
N-myc downstream regulated gene 1 modulates Wnt-β-catenin signalling and pleiotropically suppresses metastasis.
Liu W, Xing F, Iiizumi-Gairani M, Okuda H, Watabe M, Pai SK, Pandey PR, Hirota S, Kobayashi A, Mo YY, et al. EMBO Mol Med. 2012 Feb; 4(2):93-108. Epub 2012 Jan 13.
EB1 is required for spindle symmetry in mammalian mitosis. [PLoS One. 2011]
EB1 is required for spindle symmetry in mammalian mitosis.
Brüning-Richardson A, Langford KJ, Ruane P, Lee T, Askham JM, Morrison EE. PLoS One. 2011; 6(12):e28884. Epub 2011 Dec 21.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

APC, signal transduction and genetic instability in colorectal cancer.
APC, signal transduction and genetic instability in colorectal cancer.
Nat Rev Cancer. 2001 Oct ;1(1):55-67.

PubMed
[The relation between Chlamydia pneumoniae infection and abdominal aortic aneury...
[The relation between Chlamydia pneumoniae infection and abdominal aortic aneurysm].
Pol Merkur Lekarski. 2001 Dec ;11(66):491-4.

PubMed
Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry...
Liquid chromatography-atmospheric pressure chemical ionisation/mass spectrometry: a rapid and selective method for the quantitative determination of ginkgolides and bilobalide in ginkgo leaf extracts and phytopharmaceuticals.
Phytochem Anal. 2002 Jan-Feb ;13(1):31-8.

PubMed
Prodrugs.
Prodrugs.
Clin J Oncol Nurs. 2001 Jan-Feb ;5(1):35.

PubMed
An evaluation of touch on a large request: a field setting.
An evaluation of touch on a large request: a field setting.
Psychol Rep. 2002 Feb ;90(1):267-9.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

APC, signal transduction and genetic instability in colorectal cancer.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Medical

Supplemental Content

Save items

Related citations in PubMed

Cited by 83 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information