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Curr Mol Med. 2001 Jul;1(3):287-96.

Role of the NF-kappaB pathway in the pathogenesis of human disease states.

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  • 1Department of Medicine, Harold Simmons Cancer Center, University of Texas Southwestern Medical Center, Dallas 75390-8594, USA.


The NF-kappaB family consists of a group of inducible transcription factors which regulate immune and inflammatory responses and protect cells from undergoing apoptosis in response to cellular stress. A number of signal transduction cascades can activate the NF-kappaB pathway to result in the translocation of the NF-kappaB proteins from the cytoplasm to the nucleus where they activate the expression of specific cellular genes. In this review, we discuss cellular genes which are regulated by NF-kappaB and disease states which are associated with constitutive activation of the NF-kappaB pathway. Strategies to prevent prolonged activation of the NF-kappaB pathway are also discussed.

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