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Genome Biol. 2002;3(3):REVIEWS1006. Epub 2002 Feb 26.

Integration of splicing, transport and translation to achieve mRNA quality control by the nonsense-mediated decay pathway.

Author information

  • 1EMBL Heidelberg, Gene Expression Programme, Meyerhofstrasse 1, 69117 Heidelberg, Germany. hentze@embl-heidelberg.de

Abstract

When pre-mRNAs are spliced, a multi-component complex is deposited onto them, close to the sites of intron removal. New findings suggest that these exon-exon junction complexes and the complexes that bind mRNA caps are key effectors of the fate of spliced mRNAs and may regulate whether mRNAs containing premature stop codons are degraded.

PMID:
11897029
[PubMed - indexed for MEDLINE]
PMCID:
PMC139025
Free PMC Article

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