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Genome Biol. 2002;3(3):COMMENT2002. Epub 2002 Feb 22.

The gentle art of gene arrangement: the meaning of gene clusters.

Author information

  • Department of Pathology, Tennis Court Road, Cambridge CB2 1QP, UK. jt233@mole.bio.cam.ac.uk

Abstract

Genome sequence comparisons reveal that some sets of genes are in similar linkage groups in different organisms while other sets are dispersed. Are some linkage groups maintained by chance, or is there an advantage to such an arrangement? Some insights may come from large clusters of genes, such as the major histocompatibility complex which includes many genes involved in immune defense.

PMID:
11897017
[PubMed - indexed for MEDLINE]
PMCID:
PMC139018
Free PMC Article

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