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J Cell Sci. 2002 Apr 1;115(Pt 7):1355-9.

Musashi: a translational regulator of cell fate.

Author information

  • 1Department of Physiology, Keio University School of Medicine, 35 Shinanomachi, Shinjuku-ku, Tokyo 160-8582, Japan. hidokano@sc.itc.keio.ac.jp

Abstract

Transcription is thought to have a major role in the regulation of cell fate; the importance of translational regulation in this process has been less certain. Recent findings demonstrate that translational regulation contributes to cell-fate specification. The evolutionarily conserved, neural RNA-binding protein Musashi, for example, controls neural cell fate. The protein functions in maintenance of the stem-cell state, differentiation, and tumorigenesis by repressing translation of particular mRNAs. In mammals it might play an important role in activating Notch signalling by repressing translation of the Notch inhibitor m-Numb.

PMID:
11896183
[PubMed - indexed for MEDLINE]
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