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Verh Dtsch Ges Pathol. 2001;85:206-7.

[Keratin 5-positive cells in the breast are progenitor cells of glandular and myoepithelial differentiation. A cell biological model as a basis of breast pathology].

[Article in German]

Author information

  • 1Gerhard-Domagk-Institut für Pathologie, Universität Münster.

Abstract

In the present computer-assisted labelling study we demonstrate for the first time that in normal breast tissue keratin (K) 5+ progenitor cells give rise to either glandular (K 8/18+) or to myoepithelial cells (sm-actin = SMA+) via intermediary cells (either K 5/6+; K 8/18+ or K 5/6+; SMA+). Furthermore we have conclusive evidence that benign proliferative breast disease lesions are progenitor cell-derived lesions. In contrast, most breast cancers appear to evolve from glandularly differentiated cells. Western blotting experiments which show large amounts of K 5 in benign proliferative breast lesions, but not in ductal carcinoma in situ confirm the immunofluorescence data. Our results pave the way towards a new cell biological model of breast regeneration, benign proliferative breast disease and breast cancer.

PMID:
11894399
[PubMed - indexed for MEDLINE]
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