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Curr Opin Genet Dev. 2002 Apr;12(2):198-209.

Histone methylation in transcriptional control.

Author information

  • Wellcome/CRC Institute and Department of Pathology, University of Cambridge, Tennis Court Road, Cambridge CB2 1QR, UK. tk106@mole.bio.cam.uk

Erratum in

  • Curr Opin Genet Dev 2002 Jun;12(3):371.


Over the past year or so, methylation of histones has come to be recognised as a major player in the regulation of gene activity. This notion follows the discovery of lysine and arginine methyltransferases and proteins that recognise the methyl-lysine 'mark' on histones. Methylated histones have been implicated in heterochromatic repression, promoter regulation and the propagation of a repressed state via DNA methylation.

[PubMed - indexed for MEDLINE]
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