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Curr Opin Genet Dev. 2002 Apr;12(2):142-8.

Histone modifications in transcriptional regulation.

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  • 1The Wistar Institute, 3601 Spruce Street, Philadelphia, Pennsylvania 19104, USA.


Covalent modifications of the amino termini of the core histones in nucleosomes have important roles in gene regulation. Research in the past two years reveals these modifications to consist of phosphorylation, methylation and ubiquitination, in addition to the better-characterized acetylation. This multiplicity of modifications, and their occurrence in patterns and dependent sequences, argues persuasively for the existence of a histone code.

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