Cell. 2002 Mar 8;108(5):583-6.

Microbial minimalism: genome reduction in bacterial pathogens.

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Department of Ecology and Evolutionary Biology, University of Arizona, Tucson, AZ 85721, USA. nmoran@u.arizona.edu

Abstract

When bacterial lineages make the transition from free-living or facultatively parasitic life cycles to permanent associations with hosts, they undergo a major loss of genes and DNA. Complete genome sequences are providing an understanding of how extreme genome reduction affects evolutionary directions and metabolic capabilities of obligate pathogens and symbionts.

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