Mol Cell. 2001 Dec;8(6):1158-60.

Thirty-three years later, a glimpse at the ribonuclease III active site.

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Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester 01655, USA.

Abstract

RNase III endonucleases cleave double-stranded RNA, transforming precursor RNAs into mature RNAs that act in pre-mRNA splicing, RNA modification, translation, gene silencing, and the regulation of developmental timing. The recently solved structure of an RNase III endonuclease domain provides a hint at how this family of ribonucleases functions.

PMID:: 11885596; [PubMed - indexed for MEDLINE]

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