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Transplantation. 2002 Feb 15;73(3):473-5.

Short course induction immunosuppression with thymoglobulin for renal transplant recipients.

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  • 1Department of Internal Medicine, Washington University School of Medicine, St. Louis, MO, USA.

Abstract

BACKGROUND:

The aim of this study was to demonstrate that 3-days of induction immunosuppression with thymoglobulin was as effective and safe as a 7-day course and reduced initial hospitalization after transplantation.

METHODS:

This was a prospective, nonrandomized trial of 40 consecutive patients receiving thymoglobulin induction for 3 days and followed for 1 year. An historical group of 48 patients that received 7 days of thymoglobulin served as controls.

RESULTS:

At 1 year, acute rejection (5 vs. 4%), graft survival (95 vs. 98%) and patient survival were similar; a composite end point of freedom from death, rejection, or graft loss, the event-free graft survival, was similar as was the safety profile. In the 3-day group, lymphocyte depletion was more sustained and initial hospitalization was significantly shorter (6 vs. 8 days).

CONCLUSION:

Three-day induction with thymoglobulin is as effective and safe as seven days, decreases initial hospitalization and causes more sustained lymphocyte depletion.

PMID:
11884948
[PubMed - indexed for MEDLINE]
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