Curr Opin Pediatr. 2002 Feb;14(1):95-8.

Cold-adapted influenza vaccines.

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Division Infectious Disease, Department of Pediatrics, Pathology, and Microbiology and Immunology, Vanderbilt University Medical Center, Nashville, Tennessee, USA.

Abstract

Because of the health impact of complicated disease from influenza in children, the role played by children in spreading influenza, and the limitations of inactivated influenza vaccine in this population, there has been ongoing effort to identify a more effective and acceptable vaccine. This review will focus on the development, limitations, and potential of a leading candidate vaccine studied in children. This is a live, attenuated, intranasally administered cold-adapted influenza vaccine.

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