Trends Pharmacol Sci. 2002 Mar;23(3):130-6.

Nicotine addiction: the possible role of functional upregulation.

Source

Dept of Pharmacology and Toxicology, TROPHOS SA, Parc Scientifique de Luminy, Marseille, France. buisson@trophos.com

Abstract

Upregulation of binding to nicotinic acetylcholine receptors (nAChRs) is observed in the brains of both smokers and animals chronically exposed to nicotine, although whether this in vivo change is accompanied by an increase in receptor function is unknown. In vitro recordings indicate that alpha4beta2- and alpha7-subtypes of nAChRs, which are the most abundant subtypes in the brain, are functionally upregulated following prolonged exposure to nicotine. The possible consequences of functional upregulation for nicotine addiction are discussed. Moreover, we propose a new paradigm that describes the unusual behavior of these neuronal nAChRs and helps to explain the effects of nicotine in the CNS and the diffuse effects of ACh.

PMID:: 11879680; [PubMed - indexed for MEDLINE]

LinkOut - more resources

Full Text Sources

Other Literature Sources

Labome Researcher Resource - ExactAntigen/Labome

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons. [J Neurosci. 2003]
Assembly of alpha4beta2 nicotinic acetylcholine receptors assessed with functional fluorescently labeled subunits: effects of localization, trafficking, and nicotine-induced upregulation in clonal mammalian cells and in cultured midbrain neurons.
Nashmi R, Dickinson ME, McKinney S, Jareb M, Labarca C, Fraser SE, Lester HA. J Neurosci. 2003 Dec 17; 23(37):11554-67.
Differential region-specific regulation of α4β2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice. [Addict Biol. 2010]
Differential region-specific regulation of α4β2* nAChRs by self-administered and non-contingent nicotine in C57BL/6J mice.
Metaxas A, Bailey A, Barbano MF, Galeote L, Maldonado R, Kitchen I. Addict Biol. 2010 Oct; 15(4):464-79. Epub 2010 Aug 23.
Nicotinic receptor subtypes in rat hippocampal slices are differentially sensitive to desensitization and early in vivo functional up-regulation by nicotine and to block by bupropion. [J Pharmacol Exp Ther. 2005]
Nicotinic receptor subtypes in rat hippocampal slices are differentially sensitive to desensitization and early in vivo functional up-regulation by nicotine and to block by bupropion.
Alkondon M, Albuquerque EX. J Pharmacol Exp Ther. 2005 May; 313(2):740-50. Epub 2005 Jan 12.
Review Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction. [Biochem Pharmacol. 2009]
Review Nicotine-induced upregulation of nicotinic receptors: underlying mechanisms and relevance to nicotine addiction.
Govind AP, Vezina P, Green WN. Biochem Pharmacol. 2009 Oct 1; 78(7):756-65. Epub 2009 Jun 18.
Review Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction. [CNS Neurol Disord Drug Targets...]
Review Neuronal nicotinic receptors as brain targets for pharmacotherapy of drug addiction.
Rahman S, López-Hernández GY, Corrigall WA, Papke RL. CNS Neurol Disord Drug Targets. 2008 Nov; 7(5):422-41.

See reviews... See all...

Cited by 31 PubMed Central articles

Neurophysiology of Nicotine Addiction. [J Addict Res Ther. 2011]
Neurophysiology of Nicotine Addiction.
Dani JA, Jenson D, Broussard JI, De Biasi M. J Addict Res Ther. 2011 Apr 20; S1(1).
Review Reward, addiction, withdrawal to nicotine. [Annu Rev Neurosci. 2011]
Review Reward, addiction, withdrawal to nicotine.
De Biasi M, Dani JA. Annu Rev Neurosci. 2011; 34:105-30.
α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease. [Open Med Chem J. 2010]
α7 Nicotinic Receptor Agonists: Potential Therapeutic Drugs for Treatment of Cognitive Impairments in Schizophrenia and Alzheimer's Disease.
Toyohara J, Hashimoto K. Open Med Chem J. 2010 May 27; 4:37-56. Epub 2010 May 27.

See all...

Related information

Related Citations
Calculated set of PubMed citations closely related to the selected article(s) retrieved using a word weight algorithm. Related articles are displayed in ranked order from most to least relevant, with the “linked from” citation displayed first.
Compound (MeSH Keyword)
PubChem chemical compound records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Substance (MeSH Keyword)
PubChem chemical substance (submitted) records that are classified under the same Medical Subject Headings (MeSH) controlled vocabulary as the current articles.
Cited in PMC
Full-text articles in the PubMed Central Database that cite the current articles.

Recent activity

Clear Turn Off Turn On

Nicotine addiction: the possible role of functional upregulation.
Nicotine addiction: the possible role of functional upregulation.
Trends Pharmacol Sci. 2002 Mar ;23(3):130-6.

PubMed
Toward an understanding of the brain substrates of reward in humans.
Toward an understanding of the brain substrates of reward in humans.
Neuron. 2002 Feb 28 ;33(5):668-71.

PubMed
Model system for evaluation of alternative splicing: exon skipping.
Model system for evaluation of alternative splicing: exon skipping.
DNA Cell Biol. 2001 Dec ;20(12):807-13.

PubMed
The present and future role of bisphosphonates in the management of patients wit...
The present and future role of bisphosphonates in the management of patients with breast cancer.
Breast Cancer Res. 2002 ;4(1):24-9. Epub 2001 Nov 26 .

PubMed
Further characterization of the interaction between the cytoskeletal proteins ta...
Further characterization of the interaction between the cytoskeletal proteins talin and vinculin.
Biochem J. 2002 Mar 15 ;362(Pt 3):761-8.

PubMed

Your browsing activity is empty.

Activity recording is turned off.

Turn recording back on

PubMed

Result Filters

Display Settings:

Send to:

Nicotine addiction: the possible role of functional upregulation.

Source

Abstract

Publication Types, MeSH Terms, Substances

Publication Types

MeSH Terms

Substances

LinkOut - more resources

Full Text Sources

Other Literature Sources

Molecular Biology Databases

Supplemental Content

Save items

Related citations in PubMed

Cited by 31 PubMed Central articles

Related information

Recent activity

Simple NCBI Directory

Getting Started

Resources

Popular

Featured

NCBI Information