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Methods Find Exp Clin Pharmacol. 2001 Nov;23(9):501-3.

Reversal of pyrogallol-induced delay in gastric emptying in rats by ginger (Zingiber officinale).

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  • 1Neuropharmacology Laboratory, Department of Pharmacology, All India Institute of Medical Sciences, New Delhi, India. ykg@hotmail.com

Abstract

The effects of the acetone extract of ginger (Zingiber officinale) was studied against pyrogallol-induced delay in gastric emptying in rats. Wistar rats of either sex, weighing between 200-250 g, were used. Pyrogallol, at a dose of 100 mg/kg i.p., significantly delayed the gastric emptying of a methyl cellulose meal. One-hour pretreatment with ginger acetone extracts (100, 250 and 500 mg/kg p.o.) reversed the pyrogallol-induced delay in gastric emptying. The effect was significant at doses of 250 and 500 mg/kg. When the low dose of ginger (100 mg/kg p.o.) was given with vitamin C and vitamin E (100 mg/kg p.o., each), the reversal of gastric emptying was more pronounced than when only two vitamins or ginger (100 mg/kg and 500 mg/kg) were given alone. The present study indicates the potential of ginger in improving symptoms such as abdominal discomfort and bloating, which may accompany several gastrointestinal illnesses.

PMID:
11876024
[PubMed - indexed for MEDLINE]
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