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    Diabetes Care. 2002 Mar;25(3):550-3.

    The Gly972Arg polymorphism in insulin receptor substrate-1 is associated with decreased birth weight in a population-based sample of Brazilian newborns.

    Bezerra RM, de Castro V, Sales T, Passini R Jr, Marba ST, Saad ST, Saad MJ.

    Departamento de Clínica Médica, Centro de Atençō Integral à Saude da Mulher-Universidade Estadual de Campinas, Campinas, Brazil.

    OBJECTIVE: We studied the association between the Gly972Arg polymorphism in insulin receptor substrate-1 (IRS-1) and birth weight in a population-based sample of Brazilian newborns. RESEARCH DESIGN AND METHODS: We studied 194 newborn children with adequate gestational age to identify the association between the Gly972Arg polymorphism and birth weight using PCR-restriction fragment length polymorphism analysis. RESULTS: The data showed that the birth weight was lower in the newborns with the Gly972Arg polymorphism in IRS-1 compared with control subjects (3,141 +/- 31.8 vs. 3,373 +/- 80.3 g, P < 0.008). The results also showed that the frequency of this polymorphism was increased in newborns with a birth weight <3,000 g (P=0.041). CONCLUSIONS: These results suggest that the genotype Gly972Arg may influence birth weight, reinforcing the hypothesis that genetically determined insulin resistance and/or reduced insulin secretion can result in impaired insulin-mediated growth in the fetus.

    PMID: 11874945 [PubMed - indexed for MEDLINE]

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