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J Endocrinol. 2002 Mar;172(3):423-40.

IGF-binding protein-5: flexible player in the IGF system and effector on its own.

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  • 1Institute of Molecular Animal Breeding, Gene Centre of the University of Munich, Feodor-Lynen-Strasse 25, D-81377 Munich, Germany. ms2278@columbia.edu

Abstract

The multiple activities of IGF-I and -II are modulated by a family of IGF-binding proteins (IGFBP-1 to -6). Although structurally related, each IGFBP has unique properties and exerts specific functions. IGFBP-5 is the most conserved IGFBP across species and was identified as an essential regulator of physiological processes in bone, kidney and mammary gland. In addition, IGFBP-5 appears to play a decisive role in the control of proliferation of specific tumour cell types. In many situations IGFBP5 exerts biological activities in the absence of IGFs, indicating the existence of IGF-independent actions. This concept was supported by the unexpected localisation of IGFBP-5 in the nucleus and the description of IGFBP-5-specific membrane-bound IGFBP-5 receptor(s). The scope of this review is to summarise the available information about the structure of IGFBP-5 and the regulation of its expression. Furthermore, the potential significance of IGFBP-5 in the regulation of physiological processes will be critically analysed in the light of recent experimental data.

PMID:
11874691
[PubMed - indexed for MEDLINE]
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