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Fertil Steril. 2002 Mar;77(3):487-90.

Estrogen raises the sweating threshold in postmenopausal women with hot flashes.

Author information

  • 1Department of Psychiatry and Behavioral Neurosciences, Wayne State University School of Medicine, Detroit, MI, USA. aa2613@wayne.edu

Abstract

OBJECTIVE:

To determine if estrogen ameliorates hot flashes by raising the core body temperature sweating threshold, by reducing core body temperature fluctuations, and/or by reducing sympathetic activation (as measured by plasma 3-methoxy-4-hydroxyphenylglycol).

DESIGN:

Laboratory physiological study.

SETTING:

University medical center.

PATIENT(S):

Twenty-four healthy postmenopausal women reporting frequent hot flashes.

INTERVENTION(S):

Participants were randomly assigned, in double-blind fashion, to receive 1 mg/d 17beta-estradiol orally or placebo for 90 days.

MAIN OUTCOME MEASURE(S):

Core body temperature, core body temperature fluctuations, mean skin temperature, sternal sweat rate, laboratory hot flash counts (sternal skin conductance), plasma 3-methoxy-4-hydroxyphenylglycol.

RESULT(S):

The E(2) group had significant increases in plasma E(2) (8 +/- 2 vs. 132 +/- 22 pg/mL) and core body temperature sweating threshold (37.98 +/- 0.09 vs. 38.14 +/- 0.09 degrees C) and decreases in plasma FSH (58.8 +/- 8.9 vs. 40.1 +/- 7.6 mIU/mL) and hot flashes (1.4 +/- 0.5 vs. 0.6 +/- 0.6). These changes did not occur in the placebo group. There were no significant changes in any other measure.

CONCLUSION(S):

E(2) ameliorates hot flashes by raising the core body temperature sweating threshold, but does not affect core temperature fluctuations or plasma 3-methoxy-4-hydroxyphenylglycol.

PMID:
11872200
[PubMed - indexed for MEDLINE]
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