Abstract
Growth hormone (GH), directly or through GH-induction of insulin-like growth factor (IGF)-1, has been implicated in lymphocyte development and function. Recent studies have questioned the role of GH and IGF-1 in immune responses. This review examines experimental data describing the immunoregulatory function of GH and attempts to reconcile the literature.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Animals
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Cell Differentiation / immunology
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Cell Differentiation / physiology
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Growth Hormone / physiology*
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Human Growth Hormone / physiology
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Humans
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Rats
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Receptors, Somatotropin / physiology
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T-Lymphocytes / immunology
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T-Lymphocytes / physiology*
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Thymus Gland / cytology
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Thymus Gland / physiology
Substances
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Receptors, Somatotropin
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Human Growth Hormone
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Growth Hormone