The role of growth hormone in T-cell development and reconstitution

J Leukoc Biol. 2002 Mar;71(3):381-7.

Abstract

Growth hormone (GH), directly or through GH-induction of insulin-like growth factor (IGF)-1, has been implicated in lymphocyte development and function. Recent studies have questioned the role of GH and IGF-1 in immune responses. This review examines experimental data describing the immunoregulatory function of GH and attempts to reconcile the literature.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Animals
  • Cell Differentiation / immunology
  • Cell Differentiation / physiology
  • Growth Hormone / physiology*
  • Human Growth Hormone / physiology
  • Humans
  • Rats
  • Receptors, Somatotropin / physiology
  • T-Lymphocytes / immunology
  • T-Lymphocytes / physiology*
  • Thymus Gland / cytology
  • Thymus Gland / physiology

Substances

  • Receptors, Somatotropin
  • Human Growth Hormone
  • Growth Hormone