Abstract
CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.
Publication types
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Research Support, U.S. Gov't, P.H.S.
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Review
MeSH terms
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Acetylation
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Adenovirus E1A Proteins / metabolism
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Alcohol Oxidoreductases / chemistry
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Amino Acid Motifs
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Animals
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BRCA1 Protein / physiology
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Cell Transformation, Neoplastic / genetics*
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Conserved Sequence
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DNA-Binding Proteins / chemistry
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DNA-Binding Proteins / genetics
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DNA-Binding Proteins / physiology*
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Drosophila Proteins / genetics
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Drosophila Proteins / physiology
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Drosophila melanogaster / genetics
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Drosophila melanogaster / metabolism
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Gene Expression Regulation, Developmental / physiology*
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Histone Deacetylases / metabolism
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Histones / metabolism
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Humans
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MDS1 and EVI1 Complex Locus Protein
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Macromolecular Substances
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Oncogenes
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Phosphoproteins / chemistry
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Phosphoproteins / physiology*
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Phosphorylation
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Protein Binding
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Protein Processing, Post-Translational
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Proto-Oncogene Proteins / physiology
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Proto-Oncogenes*
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Repressor Proteins / chemistry
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Repressor Proteins / classification
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Retinoblastoma Protein / physiology
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Transcription Factors*
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Transcription, Genetic
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Vertebrates / genetics
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Vertebrates / metabolism
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Wnt Proteins
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Xenopus laevis / embryology
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Xenopus laevis / genetics
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Zebrafish Proteins*
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ras Proteins / physiology
Substances
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Adenovirus E1A Proteins
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BRCA1 Protein
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DNA-Binding Proteins
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Drosophila Proteins
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Histones
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MDS1 and EVI1 Complex Locus Protein
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MECOM protein, human
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Macromolecular Substances
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Phosphoproteins
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Proto-Oncogene Proteins
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Repressor Proteins
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Retinoblastoma Protein
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Transcription Factors
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Wnt Proteins
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Zebrafish Proteins
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Alcohol Oxidoreductases
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2-hydroxyacid dehydrogenase
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C-terminal binding protein
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Histone Deacetylases
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ras Proteins