CtBP, an unconventional transcriptional corepressor in development and oncogenesis

Mol Cell. 2002 Feb;9(2):213-24. doi: 10.1016/s1097-2765(02)00443-4.

Abstract

CtBP family proteins are conserved among vertebrates and invertebrates and function as transcriptional corepressors. They repress transcription in a histone deacetylase-dependent or -independent manner. CtBPs play important roles during development and oncogenesis. In this review, their unusual properties, the mechanisms of transcriptional repression, regulation, and their biological functions are discussed.

Publication types

  • Research Support, U.S. Gov't, P.H.S.
  • Review

MeSH terms

  • Acetylation
  • Adenovirus E1A Proteins / metabolism
  • Alcohol Oxidoreductases / chemistry
  • Amino Acid Motifs
  • Animals
  • BRCA1 Protein / physiology
  • Cell Transformation, Neoplastic / genetics*
  • Conserved Sequence
  • DNA-Binding Proteins / chemistry
  • DNA-Binding Proteins / genetics
  • DNA-Binding Proteins / physiology*
  • Drosophila Proteins / genetics
  • Drosophila Proteins / physiology
  • Drosophila melanogaster / genetics
  • Drosophila melanogaster / metabolism
  • Gene Expression Regulation, Developmental / physiology*
  • Histone Deacetylases / metabolism
  • Histones / metabolism
  • Humans
  • MDS1 and EVI1 Complex Locus Protein
  • Macromolecular Substances
  • Oncogenes
  • Phosphoproteins / chemistry
  • Phosphoproteins / physiology*
  • Phosphorylation
  • Protein Binding
  • Protein Processing, Post-Translational
  • Proto-Oncogene Proteins / physiology
  • Proto-Oncogenes*
  • Repressor Proteins / chemistry
  • Repressor Proteins / classification
  • Retinoblastoma Protein / physiology
  • Transcription Factors*
  • Transcription, Genetic
  • Vertebrates / genetics
  • Vertebrates / metabolism
  • Wnt Proteins
  • Xenopus laevis / embryology
  • Xenopus laevis / genetics
  • Zebrafish Proteins*
  • ras Proteins / physiology

Substances

  • Adenovirus E1A Proteins
  • BRCA1 Protein
  • DNA-Binding Proteins
  • Drosophila Proteins
  • Histones
  • MDS1 and EVI1 Complex Locus Protein
  • MECOM protein, human
  • Macromolecular Substances
  • Phosphoproteins
  • Proto-Oncogene Proteins
  • Repressor Proteins
  • Retinoblastoma Protein
  • Transcription Factors
  • Wnt Proteins
  • Zebrafish Proteins
  • Alcohol Oxidoreductases
  • 2-hydroxyacid dehydrogenase
  • C-terminal binding protein
  • Histone Deacetylases
  • ras Proteins