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Curr Biol. 2002 Feb 19;12(4):R141-3.

Polyglutamine disease: acetyltransferases awry.

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  • Division of Medical Genetics, Box 357720, University of Washington, Seattle, Washington 98195, USA. rehughes.u.washington.edu

Abstract

Recent evidence indicates that inhibition of histone acetyltransferases may be a primary cause of cellular pathogenesis in polyglutamine diseases such as Huntington disease; the results raise the possibility that pharmacologic manipulation of protein acetylation levels could be of therapeutic benefit.

PMID:
11864588
[PubMed - indexed for MEDLINE]
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