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1: Genome Biol. 2002;3(2):REVIEWS0002. Epub 2002 Jan 14.Click here to read Click here to read Links

The evolutionary history of effectors downstream of Cdc42 and Rac.

Cotteret S, Chernoff J.

Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA. J_Chernoff@fccc.edu

Cdc42 and Rac--ancient, highly conserved, small GTPases--mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac.

PMID: 11864373 [PubMed - indexed for MEDLINE]

PMCID: PMC139012