Genome Biol. 2002;3(2):REVIEWS0002. Epub 2002 Jan 14.

The evolutionary history of effectors downstream of Cdc42 and Rac.

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Fox Chase Cancer Center, 7701 Burholme Ave, Philadelphia, PA 19111, USA. J_Chernoff@fccc.edu

Abstract

Cdc42 and Rac--ancient, highly conserved, small GTPases--mediate extracellular signals, triggering changes in transcription and in the actin cytoskeleton. Although dozens of proteins act downstream of these GTPases, a comparison of effector proteins from evolutionarily diverse organisms suggests that six groups of proteins serve as the core machinery for signaling from Cdc42 and Rac.

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PMCID:: PMC139012

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