Bioinformatics Research Group, AI Center, SRI International, Menlo Park, CA 94025, USA. pkarp@ai.sri.com
Annotation, the process by which structural or functional information is inferred for genes or proteins, is crucial for obtaining value from genome sequences. We define the process of annotating a previously annotated genome sequence as 're-annotation', and examine the strengths and weaknesses of current manual and automatic genome-wide re-annotation approaches.